- Umatilla Indian Reservation, an Indian reservation in Oregon
- Confederated Tribes of the Umatilla Indian Reservation, a Native American tribal entity in the U.S. state of Oregon
- Umatilla people, a Native American tribe from Oregon
- Umatilla language, a Native American language from the Plateau Penutian group
- Umatilla, Oregon, a city located in Umatilla County, Oregon
- Umatilla, Florida, a city in Lake County, in the U.S. state Florida. The name, Umatilla, was registered with the U.S. Land Office in Gainesville in 1876; was taken from an Oregon town of the same name; is an Indian name meaning "laughing waters."
- Umatilla County, Oregon, a county in Oregon